Adding LC-MS/MS or GC-MS Capability to a Laboratory
LC-MS/MS suits polar, non-volatile and thermally labile compounds; GC-MS suits volatile and semi-volatile compounds. Adding either means the instrument plus sample preparation, gases, data systems and trained analysts, and new methods must be validated for your matrices before results are reported.
Typical equipment
- LC-MS/MS (triple quadrupole) or high-resolution MS as the application requires
- GC-MS with autosampler, headspace or thermal desorption where needed
- Nitrogen generator, carrier gases and exhaust
- Sample preparation: SPE, QuEChERS, evaporators, centrifuges
- Chromatography data system with appropriate data integrity controls
Staffing and validation
Mass spectrometry needs experienced analysts for method development and troubleshooting. Budget time for method validation and, in regulated settings, instrument qualification.
Questions to answer before buying equipment
- Which methods or standards must the laboratory run, and at what edition?
- What sample types, sizes and annual volumes are expected?
- Are accredited (ISO/IEC 17025) results required for customers or regulators?
- What utilities, floor loading, ventilation and environmental control does the space provide today?
- Who will calibrate, service and qualify the equipment, and how quickly can they respond?
- Would outsourcing some work until volumes justify the investment be more economical?
Common questions
- How long does it take to bring a new MS method online?
- It depends on the method, matrices and regulatory context; validation and qualification often take longer than installation. Instrument suppliers and consultants can help plan the schedule.