Adding PFAS Testing Capability to an Environmental Laboratory

Adding PFAS testing usually means an LC-MS/MS system, solid-phase extraction, isotopically labelled standards and a rigorous contamination-control programme, because PFAS are present in many common laboratory materials. Laboratories typically target a published method such as EPA Method 1633 or EPA 533/537.1 and must demonstrate performance before reporting data.

Typical equipment

  • LC-MS/MS (triple quadrupole) with PFAS delay column
  • Solid-phase extraction equipment and evaporators
  • Isotopically labelled and native PFAS standards
  • PFAS-free sample containers, tubing and consumables

Facility and quality considerations

Replace PTFE components in the flow path where methods require, screen consumables and water for background PFAS, and plan blanks, spikes and proficiency testing. Data review and reporting for PFAS lists can be demanding — confirm LIMS support.

Questions to answer before buying equipment

  • Which methods or standards must the laboratory run, and at what edition?
  • What sample types, sizes and annual volumes are expected?
  • Are accredited (ISO/IEC 17025) results required for customers or regulators?
  • What utilities, floor loading, ventilation and environmental control does the space provide today?
  • Who will calibrate, service and qualify the equipment, and how quickly can they respond?
  • Would outsourcing some work until volumes justify the investment be more economical?

Common questions

Can we add PFAS to an existing LC-MS/MS?
Sometimes, with a PFAS delay column and replacement of fluoropolymer components, but sensitivity and dedicated use are common concerns. Discuss with instrument suppliers before committing.

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